ESR03
WP2. Optimization of acid-sensing ion channels for sustained pH sensing.
Recruiting institution: University of Lausanne
Location: Lausanne, Switzerland
Supervisors: Stephan Kellenberger, Ivan Gautschi
Project description:
The project involves mutagenesis of acid-sensing ion channels to produce a sustained response to pH changes, electrophysiological characterization of these mutants, and expression as fusion protein and biochemical purification of selected mutants.
Secondments:
École Polytechnique Fédérale de Lausanne (Switzerland). Protein expression and purification.
University of Warsaw (Poland). Electrical properties measurements on planar lipid bilayers with ion channels.
PhD awarding entity: University of Lausanne
Qualifications: Those beside of the generall call.
Skills: Practical knowledge of molecular biology techniques, electrophysiology and biochemistry of proteins will be an advantage.
Experience: Those beside of the general call.
Expected start day: September-October, 2021